"Skeletal Diseases"

Definition
Fanconi syndrome is a disorder of the kidney tubes in which certain substances normally absorbed into the bloodstream by the kidneys are released into the urine instead.
Symptoms
Fanconi syndrome is characterised by the following symptoms:

• Passing large amounts of urine, which can lead to dehydration
• Bone pain
• Weakness

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Definition
Skeletal limb abnormalities is a very broad descriptive term. There are a variety of possible abnormalities of the arms or legs (limbs) that can be caused by underlying defects in the skeletal structure.
Considerations
Skeletal limb abnormalities may result from:

• Metabolic diseases
• Malnutrition (inadequate amounts of a vitamins, proteins, calcium, or other nutrients)
• Genetic diseases and chromosomal abnormalities
• Problems experienced by a fetus before birth — exposure to drugs and medications, infections, positioning, or injury
• Birth trauma
• Cancers

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Definition
An adamantinoma is a slow growing cancerous bone tumor that is most often found in the shin bone (tibia) or the jaw bone (mandible). Sometimes, these tumors might be found in the forearm, hands or feet. It is a rare tumor, occurring primarily in males between the ages of 10-30, usually after skeletal maturity is reached.
In about 20 percent of cases, adamantinoma cancer cells spread to other parts of the body (metastasize), usually to the lungs or nearby lymph nodes.
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Bone: Your body has 206 bones, that serve multiple different functions:

1. - they provide structure to the body and help provide its shape. Muscles attach to the bones and allow you to move. Without the bones you would be unable to stand, walk, or move.
2. - the bones help to protect the more fragile organs of the body.
   e.g.:       the bones of the skull protect the brain
   the vertebrae of the spine protect the spinal cord
   the ribs protect the heart and lungs
3. - the bones contain bone marrow, which makes and stores new blood cells.
4. - the bones help control your body’s collection of various proteins and nutrients including calcium and phosphorus

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